HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Patel, V. Articles by Connolly, C. Search for Related Content PubMed PubMed Citation Articles by Patel, V. Articles by Connolly, C.

Cytokine profiles in HIV seropositive patients with tuberculous meningitis

¹ Division of Neurology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
² Biostatistics, Medical Research Council, Durban, South Africa

Correspondence to:
Correspondence to:
Dr VB Patel, Department of Neurology, Ward A3, Wentworth Hospital, Private Bag Jacobs, Durban 4026, South Africa;
patelv@nu.ac.za

Keywords: human immunodeficiency virus; cytokines; tuberculous meningitis

The first 150 words of the full text of this article appear below.

The immunological response in pulmonary and pleural tuberculosis has been extensively studied. However, the response in tuberculous meningitis has not been well documented.¹ In pulmonary disease, exposure to tuberculous antigens results in a T cell and natural killer cellular response, elaborating various cytokines, mainly of T helper type 1 (Th1) origin. Stimulated macrophages elaborate tumour necrosis factor (TNF) , interleukin (IL) 12, and IL 1, promoting further recruitment and activation of macrophages and lymphocytes.

TNF correlates with disease severity and may contribute to tissue necrosis; however, TNF has also contributed to survival in mouse studies.² Transforming growth factor ß (Th3 cytokine) suppresses macrophage activation. IL 2 may be beneficial in promoting an immune response in HIV seropositive patients. Th1 and Th2 cytokine responses have been observed in cerebrospinal fluid (CSF) of HIV seronegative patients with tuberculous meningitis.^3,4. Whether the response is similar in HIV seropositive patients with tuberculous meningitis . . . [Full text of this article]

This article has been cited by other articles:

				V. Patel, A. Bhigjee, P. Bill, and C. Connolly Cytokine profiles in HIV seropositive patients with tuberculous meningitis Sex. Transm. Inf., February 1, 2003; 79(1): 75 - 76. [Full Text] [PDF]