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Blood–brain barrier permeability in type II diabetes

Department of Neurology, Royal Free Hospital, London NW3 2QG

Correspondence to:
Correspondence to:
J V Bowler;
j.bowler@rfc.ucl.ac.uk

Keywords: diabetes mellitus; blood; brain barrier; cognitive impairment

The first 150 words of the full text of this article appear below.

Diabetes has an important and readily demonstrable association with cognitive impairment and stroke. Starr et al, in their paper on page,¹ have concentrated on a more subtle pathology, that of leukoaraiosis. They have shown increased blood–brain barrier permeability in well controlled diabetic patients and in association with leukoaraiosis in both patients and controls. The authors also draw attention to the poorly recognised association between diabetes, impaired cognition, and leukoaraiosis. When leukoaraiosis was first seen on CT and later on MRI it was routinely dismissed as unimportant. However, leukoaraiosis is associated with cognitive impairment and increases the risk of dementia when seen in conjunction with other dementing illnesses, whether these be primarily degenerative such as Alzheimer’s disease, or vascular.² Its influence is often subtle in individuals, but in populations it makes a significant contribution to cognitive impairment.

While hypertension is the most important risk factor . . . [Full text of this article]

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Increased blood–brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging

J M Starr, J Wardlaw, K Ferguson, A MacLullich, I J Deary, and I Marshall
J. Neurol. Neurosurg. Psychiatry 2003 74: 70-76. [Abstract] [Full Text] [PDF]