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Head injury outcome prediction in the emergency department: a role for protein S-100B?

¹ Department of Neurology, Otto-von-Guericke University, Leipziger Straße 44, Magdeburg 39120, Germany; michael.wunderlich@medizin.uni-magdeburg.de

Keywords: head injury; prediction; protein S-100B

The first 150 words of the full text of this article appear below.

I read with great interest the recent article by Townend et al¹ in which the authors studied the predictive value of protein S-100B in patients with head injury upon performance in the extended Glasgow outcome scale (GOSE). One important criticism is that the study was performed in patients with head injury defined as "any blow to the head causing a clinical diagnosis of head injury to be made, even if insufficient to cause definite loss of consciousness" and not only in patients with traumatic brain injury, which is defined at least through loss of consciousness, amnesia, or postconcussion syndrome. Consequently, relevant abnormality of the brain even in minor traumatic brain injury was only detected in a few patients.

In addition, cerebral computed tomography (CT) was only performed in 15 of 148 patients. The extent of possible traumatic brain injury in the patients in the study by Townend et al¹ cannot . . . [Full text of this article]

W Townend², B Martin², D Yates², M Guy³

² Emergency Department, Hope Hospital, Stott Lane, Salford M6 8HD, UK
³ Biochemistry Department, Hope Hospital

Correspondence to:
Correspondence to:
Dr W Townend;
wtownend@fs1.ho.man.ac.uk

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