HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Brown, D M Articles by Levine, S R Search for Related Content PubMed PubMed Citation Articles by Brown, D M Articles by Levine, S R Related Collections Other Neurology Interventional radiology Related Article

Clinical radiologic correlations in acute stroke: is the signal intensity at the end of the tunnel getting brighter quicker?

Stroke Program, Department of Neurology, The Mount Sinai School of Medicine, New York, NY 10029–6574, USA

Correspondence to:
Correspondence to:
S R Levine, Stroke Program, Department of Neurology, Box 1137, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029–6574, USA;
steven.levine@mssm.edu

Keywords: acute stroke; time to clot lysis; cerebral ischemia; DWI-PWI mismatch

The first 150 words of the full text of this article appear below.

Current practice relies on time dependent criteria for decisions regarding acute stroke therapy. This is based on the results of the NINDS rt-PA Stroke Trial,^1–2 animal,³ and other clinical studies⁴ that indicate that time to clot lysis is the key factor predicting outcome after focal cerebral ischaemia. We know that every patient at the same time from symptom onset of ischaemic stroke does not benefit equally from acute therapies. Factors other than time, such as collateral circulation, stroke aetiology, permanent versus intermittent occlusive process, coagulation state, age, underlying disease state (eg diabetes mellitus, hypertension, haematocrit), sex, and other genetic factors, are likely to influence response to thrombolysis and other acute therapies.⁵ Current investigations are seeking alternate protocols, biological markers, and criteria for acute therapy, some of which are based on imaging of the purported ischaemic core and penumbra.⁶ The study by Adler et al⁷ (pp 886–888, this . . . [Full text of this article]

Related Article

Differences in the diagnostic accuracy of acute stroke clinical subtypes defined by multimodal magnetic resonance imaging

S J Allder, A R Moody, A L Martel, P S Morgan, G S Delay, J R Gladman, and G G Lennox
J. Neurol. Neurosurg. Psychiatry 2003 74: 886-888. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

				C. K. Kuhl, J. Textor, J. Gieseke, M. von Falkenhausen, S. Gernert, H. Urbach, and H. H. Schild Acute and Subacute Ischemic Stroke at High-Field-Strength (3.0-T) Diffusion-weighted MR Imaging: Intraindividual Comparative Study Radiology, February 1, 2005; 234(2): 509 - 516. [Abstract] [Full Text] [PDF]