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Mental deterioration late after head injury—does it happen?

Rehab Without Walls, 27 Presley Way, Crownhill, Milton Keynes MK8 0ES, UK; nbrooks@rww.org.uk

Keywords: APOE status; cognition; head injury

The first 150 words of the full text of this article appear below.

The possibility of late mental deterioration after head injury has been raised for many years, although infrequently until recently. It is now becoming quite a hot topic, with three separate and interacting strands of research and ideas. The first of the three interrelated topics is the work on genetic factors in recovery after head injury. The second is the possible relation between head injury and later onset of Alzheimer’s disease. The third is the possible relation between head injury and (much) later cognitive deterioration.

There is certainly evidence to draw on in all three areas, although probably it is the former in which information is the least ambiguous, with evidence of a relation between genetic factors (APOE status) and early recovery/outcome after head injury. One problem with all these areas of research is the practical difficulty of obtaining good research data. To do so demands . . . [Full text of this article]

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Long term neuropsychological outcome after head injury: relation to APOE genotype

K Millar, J A R Nicoll, S Thornhill, G D Murray, and G M Teasdale
J. Neurol. Neurosurg. Psychiatry 2003 74: 1047-1052. [Abstract] [Full Text] [PDF]

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				V. Raymont, A. Greathouse, K. Reding, R. Lipsky, A. Salazar, and J. Grafman Demographic, structural and genetic predictors of late cognitive decline after penetrating head injury Brain, February 1, 2008; 131(2): 543 - 558. [Abstract] [Full Text] [PDF]