HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Surtees, R Search for Related Content PubMed Articles by Surtees, R

Lysosomal disorders of the brain: recent advances in molecular and cellular pathogenesis and treatment

The first 150 words of the full text of this article appear below.

This is a marvellous book. It is comprehensive in its coverage and also gives much hope for the future. The authors of the individual chapters are held in international renown for their work and on the whole the book is skilfully edited and beautifully set.

The book addresses recent advances in molecular and cellular pathogenesis, and treatment of lysosomal disorders of the brain. The book is organised into four sections. Firstly, there is an overview of the endosomal-lysosomal system and storage disorders. This includes the known biology of the endosomal-lysosomal system, a new way of classifying lysosomal diseases on the basis of the molecular defects, and the clinical approach and diagnosis. The next section examines the molecular mechanisms of storage. This includes the primary defects in lysosomal enzymes, defects in lysosomal enzyme modification, trafficking and protection, and defects in activator proteins and in lysosomal transmembrane proteins. This is followed by . . . [Full text of this article]