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Traumatic brain injury as a risk factor for Alzheimer’s disease

Institute of Clinical Neurobiology, Kenyongasse 18, A-1070 Vienna, Austria; kurt.jellinger@univie.ac.at

Keywords: brain injury; Alzheimers disease; ApoE

The first 150 words of the full text of this article appear below.

In a recent systematic review of case control studies investigating head injury as a risk factor for Alzheimer’s disease (AD), Fleminger et al¹ replicated the results of the meta-analysis by Mortimer et al² in males (OR 2.29; 95% CI from 1.47 to 2.00) but not in females (OR 0.91; 95% CI from 0.56 to1.47). Their findings support in males only an association between a history of previous head injury and the risk of developing AD, but the study could not review the relation between head injury and ApoE gene status as risk factors for AD.

The review by Fleminger et al was based on clinical studies alone and, as Wilson³ emphasised, did not consider the nature or severity of the original head injury; and the results of the first retrospective autopsy study of the relation between closed traumatic brain injury (TBI), ApoE allele frequency, and AD^4,5 unfortunately were not mentioned. . . . [Full text of this article]