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Genes for stroke

Correspondence to:
Correspondence to:
Professor H Markus
Clinical Neuroscience, St George’s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK; h.markus@sghms.ac.uk

Abbreviations: CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy; IMT, intima media thickness; MRI, magnetic imaging resonance; PDE, phosphodiesterase

Keywords: CADASIL; genetics; stroke; phosphodiesterase 4D

The first 150 words of the full text of this article appear below.

Half the risk of ischaemic stroke remains unexplained by conventional risk factors¹ and genetic predisposition has been widely speculated to account for some of this unexplained risk.² Although significant progress has been made unravelling the basis of single gene stroke disorders, identifying the underlying genes for common or multifactorial stroke, for which there is no obvious Mendelian pattern of inheritance, has proved difficult. Has this situation changed with the recent publication of the first independent risk gene for common stroke?³

ARE GENETIC FACTORS IMPORTANT IN STROKE RISK?
What is the evidence that genetic risk factors are important in stroke risk? Twin studies suggest a modest genetic component, more important in younger individuals.^4,5 Many studies have determined whether a family history of stroke is more common in stroke cases compared with normal controls.^2,6 Most report an association, which is stronger both in younger individuals and with certain stroke subtypes, particularly small vessel disease (lacunar) and large . . . [Full text of this article]

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