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Stiff person syndrome with eye movement abnormality, myasthenia gravis, and thymoma

¹ Department of Ophthalmology, University Hospitals Leicester, Leicester, UK
² Department of Neurology, University Hospitals Leicester
³ Ophthalmology, University of Leicester, Leicester, UK
⁴ Department of Neurology, University Hospitals Leicester
⁵ Ophthalmology, University of Leicester
⁶ Department of Neurology, University of Nottingham, Nottingham, UK
⁷ Ophthalmology, University of Leicester

Correspondence to:
Correspondence to:
Professor I Gottlob
University of Leicester, RKCSB, PO Box 65, Leicester, LE2 7LX; ig15@leicester.ac.uk

Keywords: stiff-person syndrome; myasthenia; thymoma

The first 150 words of the full text of this article appear below.

Stiff person syndrome (SPS) is a rare disorder of the central nervous system characterised by progressive fluctuating rigidity and painful spasms of the body musculature. We describe a patient with SPS with positive glutamic acid decarboxylase (GAD) antibodies who developed diplopia. Thymoma was detected by computed tomography (CT), and after thymectomy his symptoms improved. One month after thymectomy, he tested positive for antiacetylcholine receptor (AchR) antibodies.

Case report
A 45 year old man presented with a four week history of back pain and stiffness of his trunk causing difficulty in bending forward and turning over while lying down, which he attributed to a minor injury sustained while playing squash. He later developed asymmetrical stiffness of the legs and difficulty walking. His past medical history was notable for an episode of dysphagia (two weeks’ duration) associated with heartburn six months ago; a gastroenterological evaluation and an endoscopy at that time were normal. He . . . [Full text of this article]

This article has been cited by other articles:

				B. Oskarsson, V. Pelak, D. Quan, D. Hall, C. Foster, and S. Galetta STIFF EYES IN STIFF-PERSON SYNDROME Neurology, July 29, 2008; 71(5): 378 - 380. [Full Text] [PDF]

				J. R. Economides and J. C. Horton Eye movement abnormalities in stiff person syndrome Neurology, November 8, 2005; 65(9): 1462 - 1464. [Abstract] [Full Text] [PDF]

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