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Mild impairments in cognition in patients with type 2 diabetes mellitus: the use of the concepts MCI and CIND

Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, Netherlands

Correspondence to:
Correspondence to:
Dr Geert Jan Biessels
Department of Neurology, G03.228, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, Netherlands; G.J.Biessels@med.uu.nl

Keywords: type 2 diabetes mellitus; mild cognitive impairment; dementia

The first 150 words of the full text of this article appear below.

Type 2 diabetes mellitus (DM2) is associated with moderate cognitive impairment in verbal memory, mental flexibility, and information processing speed, while other cognitive functions remain relatively unaffected.¹ Moreover, epidemiological studies have shown that DM2 patients have a twofold increased risk of developing either vascular dementia or Alzheimer’s disease.^1,2 In the present study we examined whether mild cognitive impairment (MCI) and "cognitive impairment, no dementia" (CIND)—two concepts that are used to describe cognitive impairment in the transitional state between normal aging and early dementia—can be applied to the cognitive impairments encountered in a population based sample of DM2 patients. Recently, these concepts have attracted considerable attention, as individuals who meet the criteria for either MCI or CIND are known to have a substantially increased risk of developing dementia.^3,4 MCI is defined as a memory deficit without impairments in other cognitive domains.³ Patients with MCI develop Alzheimer’s disease at an annual incidence . . . [Full text of this article]