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Disseminated Pseudallescheria boydii infection successfully treated with voriconazole

¹ Department of Neurology, University of California, Los Angeles, CA, USA
² Saint Luke’s Hospital, Chesterfield, MO, USA
³ Department of Neurology, University of Iowa, Iowa City, IA, USA

Correspondence to:
Correspondence to:
Dr L G Apostolova
Tichi Wilkerson-Kassel Dementia Fellow, Department of Neurology, University of California at Los Angeles, Reed Neurological Research Center 2–238, 710 Westwood Plaza, Los Angeles, CA 90095, USA; lapostolova@mednet.ucla.edu

Keywords: Pseudallescheria boydii; septic emboli; stroke; endocarditis; voriconazole

The first 150 words of the full text of this article appear below.

A 56 year old, right handed African-American man with past history of left knee osteoarthritis, remote intravenous drug use, remote alcoholism, and seropositivity for hepatitis C was admitted to a local hospital for fatigue, chest pain, 13.6 kg weight loss, night sweats, and vision loss. On examination, a loud systolic murmur was present. An electrocardiogram (ECG) displayed T wave alternans and a transoesophageal echocardiogram revealed severe mitral regurgitation with mitral valve vegetations, ruptured chordae tendineae, and left ventricular ejection fraction of 75%. He was diagnosed as having endocarditis and cytomegalovirus endophthalmitis, and was treated with ceftriaxone, vancomycin, ganciclovir, foscarnet, aspirin, metoprolol, lisinopril, nifedipine, and intravenous esmolol. He developed fever (39.3°C) and his mental status declined. A head computed tomography (CT) scan showed left occipital haemorrhage. His left leg became cold and pale with an ankle:brachial index of 0.4. Blood cultures grew yeast. Amphotericin B was started and he was transferred . . . [Full text of this article]

This article has been cited by other articles:

				F. Gilgado, C. Serena, J. Cano, J. Gene, and J. Guarro Antifungal Susceptibilities of the Species of the Pseudallescheria boydii Complex Antimicrob. Agents Chemother., December 1, 2006; 50(12): 4211 - 4213. [Abstract] [Full Text] [PDF]