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Journal of Neurology Neurosurgery and Psychiatry 2005;76:159-160
© 2005 BMJ Publishing Group Ltd

EDITORIAL COMMENTARY
Stroke

Mapping anterograde and retrograde degeneration after stroke

J-C Baron

Correspondence to:
Correspondence to:
Professor Jean-Claude Baron
University of Cambridge, Department of Neurology, Addenbrookes Hospital, Box 83, Cambridge CB2 2QQ, UK; jcb54@cam.ac.uk

Tools to quantify secondary degeneration after stroke and monitor effects of intervention

Keywords: Diffusion tensor imaging; imaging; stroke

The first 150 words of the full text of this article appear below.

In this issue, two original articles from highly experienced groups report on the use of diffusion tensor imaging (DTI) to map the dynamics of secondary degeneration after stroke (see pp 200–5 and 266–8). Thomalla et al1 monitored in two patients the time course of Wallerian degeneration (WD) of the pyramidal tract following striatocapsular stroke. DTI was obtained on three occasions from the subacute into the chronic stage. They found a progressive decrease of the fractional anisotropy (FA) with an increase in mean diffusivity (MD) in the pyramidal tract at the level of the cerebral peduncle, reflecting the changes expected in WD—a progressive disintegration of fibre structure. Hervé et al2 serially studied nine patients from 1 week to 6 months following MCA territory stroke, focusing on the ipsilateral thalamus. They found significant increases in MD from 1 month onward, without parallel changes in FA, presumably reflecting a progressive . . . [Full text of this article]


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