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Severe malaria: still counting the costs

¹ Departments of Neurology & Epidemiology, Michigan State University, MI, USA
² College of Osteopathic Medicine’s Department of Internal Medicine, Michigan State University

Correspondence to:
Correspondence to:
Gretchen L Birbeck
Assistant Professor, Departments of Neurology & Epidemiology, 138 Service Road, A217, East Lansing, MI 48824-1313, USA; Gretchen.Birbeck@ht.msu.edu

Keywords: Cerebral malaria; severe malaria

The first 150 words of the full text of this article appear below.

The burden of malaria in the developing world has largely been measured in terms of childhood mortality. Annually, 300–500 million infections occur resulting in 1 million deaths; these account for 20% of childhood mortality in malaria endemic regions.¹ An article by Carter et al (this issue, pp 476–81) provides evidence that the burden of malaria includes chronic neurological consequences among survivors.²

The possibility that survivors of severe malaria suffer from neurological sequelae such as cognitive deficits or epilepsy has been suggested.³ Certainly, gross deficits at hospital discharge among a small proportion of survivors have been reported, but until recently, little systematic data on long term outcomes of severe malaria were available. Previous studies have suffered from loss to follow-up, short duration of follow-up, the lack of a comparison population, and evaluations limited to a bedside assessment.

The study by Carter et al utilised the Kilifi District Hospital database . . . [Full text of this article]

Relevant Article

Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children

J A Carter, V Mung’ala-Odera, B G R Neville, G Murira, N Mturi, C Musumba, and C R J C Newton
J. Neurol. Neurosurg. Psychiatry 2005 76: 476-481. [Abstract] [Full Text] [PDF]