HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Sinzinger, H Search for Related Content PubMed PubMed Citation Articles by Sinzinger, H Related Collections Other Cardiovascular Medicine Stroke

Does the risk factor profile have predictive value for the site of atherosclerosis?

Correspondence to:
Correspondence to:
Professor H Sinzinger
Institute for Diagnosis and Treatment of Atherosclerosis and Lipid Disorders (ATHOS), Nadlergasse 1, A-1090 Vienna, Austria; helmut.sinzinger@meduniwien.ac.at

Keywords: atherosclerosis; inflammation; risk factors

The first 150 words of the full text of this article appear below.

Atherosclerosis is increasingly linked with inflammation, a claim already made by Rudolf Virchow in 1856. Vascular biology has demonstrated that inflammation also plays a key role in stroke development. The best examined inflammatory marker is C-reactive protein (CRP). High sensitivity (hs)-CRP predicts the risk not reflected by traditional risk factors¹ for stroke and coronary heart disease (CHD). Interleukin-6 is an even better predictor than CRP and correlates with stroke severity, infarct volume, and long term outcome and is an independent predictor of stroke²; hs-CRP is a more valuable predictor than low density lipoprotein cholesterol (LDL). As hs-CRP and LDL are additive predictors, they identify different risk factors.

The CRP gene markedly accelerates atherosclerosis, indicating an active role. CRP is locally generated within the arterial wall. Intraplaque inflammation may attenuate invasion of endothelial progenitor cells and has been postulated to play a crucial role in thinning of . . . [Full text of this article]