JNNP

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
Journal of Neurology, Neurosurgery, and Psychiatry 2005;76:1185-1186; doi:10.1136/jnnp.2005.064766
Copyright © 2005 by the BMJ Publishing Group Ltd.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leys, D
Right arrow Articles by Bombois, S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leys, D
Right arrow Articles by Bombois, S
Topic Collections
Right arrowRelevant Articles

EDITORIAL COMMENTARY
White matter hyperintensities

White matter hyperintensities: a target for the prevention of cognitive decline?

D Leys1, S Bombois2

1 Department of Neurology, Stroke, EA2691, Lille University Hospital, Lille, France
2 Department of Neurology, Memory Units, EA2691, Lille University Hospital, Lille, France

Correspondence to:
Correspondence to:
D Leys
Department of Neurology (EA2691), Lille University Hospital, F-59037 Lille, France; dleys@chru-lille.fr

Lowering blood pressure might decrease the rate of cognitive decline in {varepsilon}4 carriers and in subjects with white matter hyperintensities, a risk factor for cognitive decline

Keywords: blood pressure; cognition; dementia; white matter hyperintensities

The first 150 words of the full text of this article appear below.

White matter hyperintensities (WMH) are frequent in apparently normal elderly subjects, in patients with vascular risk factors such as high blood pressure levels, in stroke patients, and in patients with either vascular dementia or Alzheimer’s disease (AD). In this issue, the papers by Garde et al (see pages 1289-91),1 Jokinen et al (see pages 1229-33),2 and de Leeuw et al (see pages 1286-8)3 provide evidence that WMH also influence cognitive functions independently of the underlying pathology. These three studies provide new information leading to potential strategies to prevent cognitive decline.

The more severe the progression of WMH over time, the more severe the cognitive decline in both AD patients3 and normal elderly subjects.1 This finding suggests that WMH should be regarded as risk factors for cognitive decline per se. Therefore, any therapeutic option that may slow the progression of WMH might . . . [Full text of this article]


Relevant Articles

White matter hyperintensities as a predictor of neuropsychological deficits post-stroke
H Jokinen, H Kalska, R Mäntylä, R Ylikoski, M Hietanen, T Pohjasvaara, M Kaste, and T Erkinjuntti
J. Neurol. Neurosurg. Psychiatry 2005 76: 1229-1233. [Abstract] [Full Text] [PDF]

Progression of cerebral white matter lesions in Alzheimer’s disease: a new window for therapy?
F-E de Leeuw, F Barkhof, and P Scheltens
J. Neurol. Neurosurg. Psychiatry 2005 76: 1286-1288. [Abstract] [Full Text] [PDF]

Decline in intelligence is associated with progression in white matter hyperintensity volume
E Garde, E Lykke Mortensen, E Rostrup, and O B Paulson
J. Neurol. Neurosurg. Psychiatry 2005 76: 1289-1291. [Abstract] [Full Text] [PDF]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2005 by the BMJ Publishing Group Ltd.