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Dramatic improvement in non-AIDS related progressive multifocal leucoencephalopathy

¹ Service de Neurologie Mazarin, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France
² Service d’Hématologie, Groupe Hospitalier Pitié-Salpêtrière

Correspondence to:
Correspondence to:
Dr Anthony Béhin
Federation de Neurologie-Mazarin, Groupe hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l’hôpital, 75013 Paris Cedex, France; anthony.behin@psl.ap-hop-paris.fr

Keywords: progressive multifocal leucoencephalopathy; neuro-infectious disease; treatment

The first 150 words of the full text of this article appear below.

Progressive multifocal leucoencephalopathy (PML) is a rare disorder occurring when a strain of papovavirus (JC virus) infects the central nervous system. It results in a generally quick and fatal outcome. It is associated with cell mediated immune deficient diseases but some few cases were reported in immunocompetent hosts. Since 1981, it has been commonly associated with AIDS. In AIDS related PML, long term survival without real neurological improvement has been reported in patients treated with highly active antiretroviral therapy (HAART).¹ Few cases of improvement with cidofovir or cytosine arabinoside have been described in AIDS related or non-AIDS-related PML,^2,3 but in larger trials in AIDS related PML, no clinical benefit was found.⁴ As a whole, the treatment of this progressive demyelinating disease remains controversial, in particular in the rare cases of non-AIDS-related PML. We describe a patient with an underlying haematological disease, without clear cut immune cell deficiency, who developed rapidly . . . [Full text of this article]

This article has been cited by other articles:

				C. H Williams-Gray, S. H Aliyu, A. M L Lever, A. F Dean, and G. G Lennox Reversible parkinsonism in a patient with progressive multifocal leucoencephalopathy J. Neurol. Neurosurg. Psychiatry, April 1, 2007; 78(4): 408 - 410. [Abstract] [Full Text] [PDF]