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Shared mechanisms of ischaemic and haemorrhagic stroke: still a lot to learn

Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Correspondence to:
Correspondence to:
Dr Patrik Michel
Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, 1011 Lausanne, Switzerland Patrik.Michel@chuv.ch

Keywords: antithrombotic treatment; ischaemic stroke; haemorrhagic stroke

The first 150 words of the full text of this article appear below.

The risk of intracerebral haemorrhage (ICH) is increased in patients with ischaemic cerebrovascular disease and vice versa.¹ Risk factors shared by both stroke subtypes, such as hypertension, age, and smoking, partly explain this observation. While some researchers stress that most ischaemic stroke subtypes have similar risk factor profiles, one can go further and claim that most strokes (ischaemic and haemorrhagic) are the result of a common final pathway: arterial wall damage with accumulation of abnormal cells and proteins, inflammation, molecular changes, and eventual breakdown of the intima and media. Hypertensive cerebral arteriolopathy and cerebral amyloid angiopathy are examples where ischaemic and haemorrhagic brain damage frequently coexist. Leukoaraiosis and microbleeds may both be markers of a single disease process affecting small cerebral arteries, putting patients at risk of both ischaemia and haemorrhages. This double risk may also explain why aggressive antithrombotic treatments fail in ischaemic stroke patients: . . . [Full text of this article]

Relevant Article

Predictors of risk of intracerebral haemorrhage in patients with a history of TIA or minor ischaemic stroke

M J Ariesen, A Algra, C P Warlow, P M Rothwell on behalf of the Cerebrovascular Cohort Studies Collaboration (CCSC)
J. Neurol. Neurosurg. Psychiatry 2006 77: 92-94. [Abstract] [Full Text] [PDF]