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Multiple sclerosis related fatigue

Correspondence to:
Correspondence to:
Dr Gavin Giovannoni
Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK; g.giovannoni@ion.ucl.ac.uk

Keywords: multiple sclerosis; fatigue

The first 150 words of the full text of this article appear below.

How we define fatigue remains as controversial today as it did 40 years ago: "True fatigue and....tiredness are plainly different."¹. Fatigue is more than tiredness and has recently been referred to as "pathological exhaustion".² In this context the term "pathological" would, for example, classify the physical fatigue which athletes experience as part of voluntary effort as being abnormal. Fatigue must therefore surely be a normal phenomenon—a subjective feeling of tiredness or exhaustion which could refer to both physical (motor activities) and mental (cognitive or emotional) processes. Fatigue is only pathological if it is disabling—that is, if it affects a person’s social, physical, and occupational wellbeing. For lack of a better definition the Centres for Disease Control and Prevention (CDC) defines "profound fatigue" and by implication "pathological fatigue" in the context of the chronic fatigue syndrome (CFS) as fatigue . . . [Full text of this article]

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Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour?

C Heesen, L Nawrath, C Reich, N Bauer, K-H Schulz, and S M Gold
J. Neurol. Neurosurg. Psychiatry 2006 77: 34-39. [Abstract] [Full Text] [PDF]

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				K. van Kessel, R. Moss-Morris, E. Willoughby, T. Chalder, M. H. Johnson, and E. Robinson A Randomized Controlled Trial of Cognitive Behavior Therapy for Multiple Sclerosis Fatigue Psychosom Med, February 1, 2008; 70(2): 205 - 213. [Abstract] [Full Text] [PDF]