JNNP

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
Published Online First: 16 June 2006. doi:10.1136/jnnp.2006.095505
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1103
Copyright © 2006 by the BMJ Publishing Group Ltd.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jnnp.2006.095505v1
77/10/1103    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Caso, V
Right arrow Articles by Paciaroni, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Caso, V
Right arrow Articles by Paciaroni, M
Topic Collections
Right arrowRelevant Article

EDITORIAL COMMENTARY
Underestimated risk for stroke patients

MTHFR 677 TT genotype and hyperhomocysteinaemia: an underestimated risk TANDEM for patients with stroke

V Caso, M Paciaroni

Stroke Unit, Ospedale Silvestrini, Perugia, Italy

Correspondence to:
Correspondence to:
V Caso
Stroke Unit, Ospedale Silvestrini, San’ Andrea delle Fratte, 06146 Perugia, Italy;vcaso@hotmail.com

Synergy between hyperhomocysteinaemia and conventional risk factors for stroke

The first 150 words of the full text of this article appear below.

Hyperhomocysteinaemia (hyperH(e)) is still considered to be one of the less documented risk factors for stroke.1 One of the most frequent causes of hyperH(e) is a single-nucleotide polymorphism in the gene methylenetetrahydrofolate reductase (MTHFR). The homozygotic TT genotype is found in approximately 10–12% of the population and is associated with a 25% higher homocysteine level in patients with than in those without this mutation.1

The distribution of the MTHFR 677 TT genotype and hyperH(e) in young patients with stroke aged <45 years was compared with that in healthy controls in the paper by Pezzini et al2 (see p 1150). The paper by Kloss et al3 compared the distribution of the MTHFR 677 TT genotype and hyperH(e) between patients with cervical artery dissections (CADs) and controls. Pezzini et al carried out a statistical analysis with a two-way and a three-way interaction and the classification . . . [Full text of this article]


Relevant Article

Interaction of homocysteine and conventional predisposing factors on risk of ischaemic stroke in young people: consistency in phenotype-disease analysis and genotype-disease analysis
A Pezzini, M Grassi, E Del Zotto, D Assanelli, S Archetti, R Negrini, L Caimi, and A Padovani
J. Neurol. Neurosurg. Psychiatry 2006 77: 1150-1156. [Abstract] [Full Text] [PDF]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2006 by the BMJ Publishing Group Ltd.