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Cognitive profile in CADASIL patients

Stroke Unit, Department of Neurosciences and Mental Health, Serviço de Neurologia, Hospital de Santa Maria, Faculdade de Medicina de Lisboa, Portugal

Correspondence to:
Correspondence to:
Lara Caeiro
Stroke Unit, Serviço de Neurologia (piso 6), Hospital de Santa Maria, Av. Professor Egas Moniz, 1649-035 Lisboa, Portugal; laracaeiro@fm.ul.pt

Keywords: CADASIL; cognitive impairment; executive functions

The first 150 words of the full text of this article appear below.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) often starts with silent lacunar infarcts or white matter changes in the third decade of life and cognitive or other neurological signs become apparent within the next 10 years. In the following 20 years, dementia and psychiatric disturbances become more and more apparent and death frequently occurs in the sixth decade of life.^1–3

Age is an important predictor of clinical deterioration, with an odds ratio of 1.10⁴ per year starting at the age of 24. Cognitive impairment affects about 60% of CADASIL patients, and psychiatric disturbances nearly 30%. Cognitive impairment initially manifests through mild executive and visuospatial deficits, psychomotor slowing, and apathy.⁵ Working and short term memory defects also appear insidiously⁶; later on, abulia and other executive dysfunctions are the main manifestations of CADASIL. Two thirds of CADASIL patients are dependent and have dementia by the time they . . . [Full text of this article]

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Cognitive profile in CADASIL

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