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PPARs: a new target for neuroprotection

¹ Département de Pharmacologie, Institut de Médecine Prédictive et de Recherche Thérapeutique, Université de Lille 2, Lille, France
² Département d’Athérosclérose, Institut de Médecine Prédictive et de Recherche Thérapeutique, Université de Lille 2, Lille, France

Correspondence to:
Correspondence to:
R Bordet
EA1046 – Département de Pharmacologie, Faculté de Médecine, 1 place de Verdun, 59045 Lille Cedex, France; bordet@univ-lille2.fr

Keywords: inflammation; neuroprotection; peroxisome proliferators-activated receptors

The first 150 words of the full text of this article appear below.

Peroxisome proliferators-activated receptors (PPARs) are ligand activated transcription factors belonging to the nuclear receptor superfamily.¹ Three isoforms of PPARs (, ß/, and ) have been identified and display distinct physiological and pharmacological functions depending on their target genes and their tissue distribution.^2,3 Indeed, the activation of PPAR, both by natural ligands such as fatty acids and eicosanoid derivates or by synthetic ligands (lipid lowering fibrates), regulates lipid and lipoprotein metabolism.⁴ Activation of PPAR by prostaglandins or by synthetic ligands, such as anti-diabetic thiazolidinediones, regulates glucose metabolism by modulating insulin sensitivity.⁴ Non-steroidal anti-inflammatory drugs are also weak agonists of PPAR and PPAR. PPARß/ is one of the most widely expressed members of the PPAR family. Until recently, the function of PPARß/ remained elusive but recent data have shown that PPARß/ also plays a key role in lipid metabolism, as it regulates serum lipid profiles and fatty . . . [Full text of this article]

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