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Paraneoplastic cerebellar degeneration: new insights into imaging and immunology

Correspondence to:
Correspondence to:
Dr J H Rees
National Hospital for Neurology and Neurosurgery, Institute of Neurology, Queen Square, London, WC1N 3BG, UK; j.rees@ion.ucl.ac.uk

Keywords: brain imaging; paraneoplastic cerebellar degeneration; brain inflammation

The first 150 words of the full text of this article appear below.

Paraneoplastic cerebellar degeneration (PCD) is still one of the most enigmatic of the autoimmune CNS disorders. It is relatively uncommon and is usually characterised by a rapid and severe cerebellar syndrome, leaving the patient dependent within a few weeks to months of onset. Brain imaging is usually remarkably unremarkable in PCD. Despite the presence of a very severe clinical deficit, the cerebellum is rarely affected radiologically at an early stage of the disease, although atrophy is usually seen some months after onset.

Three papers present unusual imaging features in PCD and provide some potential new insights into the pathogenesis of this disease (see pages 525, 529, 562 of this issue). The paper by Scheid et al reports cerebellar atrophy occurring within 1 month of symptom onset.¹ The patient had had an MRI brain scan carried out a year earlier to investigate migraine and . . . [Full text of this article]

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