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Unusual magnetic resonance imaging and cerebrospinal fluid findings in paraneoplastic cerebellar degeneration: a sequential study

¹ Department of Neurology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
² Department of Radiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
³ Department of Neurology, Hospital Clinic, Barcelona, Spain
⁴ Department of Immunology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

Correspondence to:
Correspondence to:
Dr C de Andrés
Department of Neurology, Hospital General Universitario "Gregorio Marañón", C/Doctor Esquerdo 46, 28007, Madrid, Spain; claradeandres@hotmail.com

Keywords: brain MRI; dendritic cells; lung cancer; paraneoplastic cerebellar degeneration

The first 150 words of the full text of this article appear below.

Paraneoplastic cerebellar degeneration (PCD) is considered to be an autoimmune disorder, the clinical symptoms of which include dizziness, blurred or double vision, oscillopsia, and gait difficulties, which are not related to direct tumour invasion, adverse effects of chemotherapy, malnutrition, or infection.¹ Some patients also develop multifocal neurological deficits through the evolution of the disease, involving multiple areas of the central nervous system (CNS), resulting in a miscellany of symptoms derived from limbic encephalitis, brainstem encephalitis, and myelitis, and known as paraneoplastic encephalomyelitis. The current pathogenic hypothesis is that the CNS lesions are immune mediated. The CSF may reveal no cells or pleocytosis and increased levels of proteins, and may exclude neoplastic cells and infections. Cranial magnetic resonance imaging (MRI) in PCD is usually normal or shows global cerebellar atrophy. Pathological studies show a diffuse loss of Purkinje cells throughout the cerebellar cortex. We describe a case of PCD with unusual . . . [Full text of this article]

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Paraneoplastic cerebellar degeneration: new insights into imaging and immunology

J H Rees
J. Neurol. Neurosurg. Psychiatry 2006 77: 427. [Extract] [Full Text] [PDF]

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				J H Rees Paraneoplastic cerebellar degeneration: new insights into imaging and immunology J. Neurol. Neurosurg. Psychiatry, April 1, 2006; 77(4): 427 - 427. [Full Text] [PDF]