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Diffuse lesion in the splenium of the corpus callosum in patients with methyl bromide poisoning

¹ Department of Neurology, Asan Mental Hospital, Asan, Republic of Korea
² Department of Neurology, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Republic of Korea
³ Department of Neurology, Kangnung Asan Hospital, University of Ulsan College of Medicine, Kangnung, Republic of Korea
⁴ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea

Correspondence to:
Correspondence to:
Dr Jae-Kyu Roh
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, 28, Yeongon-dong, Jongno-gu, Seoul, 110-744, Republic of Korea; rohjk@snu.ac.kr

Keywords: methyl bromide; poisoning; splenium of corpus callosum

The first 150 words of the full text of this article appear below.

Imaging abnormalities of the splenium of the corpus callosum (SCC) are uncommon but have been described in various clinical conditions such as Marchiafava-Bignami disease, trauma, infectious diseases, acute disseminated encephalomyelitis, epilepsy, altitude sickness, hypoglycaemia, electrolyte abnormalities, leukodystrophy, and infarction, and following radiation therapy and chemotherapy.^1,2 We have detected a diffuse lesion in the SCC of two patients with methyl bromide intoxication.

Case report 1
The first case involved a previously healthy 31 year old man. He had worked in a fumigating plant spraying strawberries for 1 month prior to admission. Strawberries were fumigated with methyl bromide for 2 h in an enclosed room. After fumigation, the room was ventilated for 10 min with electric fans. Thereafter, the subject transferred the fumigated fruits to a warehouse. He worked for 3 h every other day. The subject reported experiencing intermittent nausea, dizziness, and ambulatory difficulty. On the day of hospital admission, the patient complained of . . . [Full text of this article]