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Leucocytoclastic vasculitic neuropathy diagnosed by biopsy of normal appearing skin

¹ Department of Neurology, Chiba University School of Medicine, Chiba, Japan
² Department of Pathology, Chiba University Hospital

Correspondence to:
Correspondence to:
Dr Satoshi Kuwabara
Department of Neurology (D3), Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan; kuwabara-s@faculty.chiba-u.jp

Keywords: leucocytoclastic vasculitis; vasculitic neuropathy; skin biopsy

The first 150 words of the full text of this article appear below.

Leucocytoclastic vasculitis (LCV) is a clinicopathological entity that preferentially involves capillaries or small vessels rather than the medium sized or large arteries typical of polyarteritis nodosa. Its histopathological features are characterised by the presence of perivascular polymorphonuclear leucocytes with fragmented nuclear debris (leucocytoclasis).¹ It may be limited to skin lesions such as erythematous macules, purpuric papules, and haemorrhagic vesiculobullous lesions. Although LCV often involves organ systems other than the skin, it is rarely associated with neurological complications, unlike polyarteritis nodosa or Churg-Strauss syndrome. We report a patient who presented with leucocytoclastic vasculitic neuropathy without skin lesions, and discuss the value of doing a combined biopsy of the skin, nerves, and muscle in this patient for the detection of vasculitis.

A 44 year old man was admitted to our hospital because of progressive asymmetrical paraesthesiae in all four limbs. Eight months before admission, a tingling sensation had begun in the second . . . [Full text of this article]