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Remission of chronic inflammatory demyelinating polyneuropathy after alemtuzumab (Campath 1H)

¹ Helen Durham Neuro-inflammatory Centre, Department of Neurology, University Hospital of Wales, Heath Park, Cardiff, UK
² Department of Clinical Neurophysiology, University Hospital of Wales
³ Department of Neurology, University Hospital of Wales, Heath Park, Cardiff CF14 4XN
⁴ Helen Durham Neuro-inflammatory Centre, Department of Neurology, University Hospital of Wales

Correspondence to:
Correspondence to:
Dr Claire Hirst
Helen Durham Neuro-inflammatory Centre, Department of Neurology, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, UK; clairewarren_uk@yahoo.co.uk

Keywords: alemtuzumab; chronic inflammatory demyelinating polyneuropathy

The first 150 words of the full text of this article appear below.

We describe a patient with intravenous immunoglobulin (IVIg) dependent relapsing chronic inflammatory demyelinating polyneuropathy (CIDP), unresponsive to steroids or conventional immunosuppressive agents, who achieved remission following treatment with alemtuzumab.

A 19 year old women presented with a two week history of distal lower limb paraesthesiae and distal upper limb weakness. Her symptoms worsened over four weeks but she remained mobile. There was no history of preceding infections, pain, or autonomic dysfunction. Examination revealed reduced limb muscle tone and distal weakness, more marked in the upper limbs. She was areflexic with flexor plantar responses and had reduced pin prick sensation in the hands and toes.

A lumbar puncture showed a raised protein of 1.8 g/l, with normal glucose and cell counts and negative oligoclonal bands. A preliminary diagnosis of Guillain-Barré syndrome was made and she was treated conservatively, with good recovery.

Three months later she developed further weakness, predominantly affecting her . . . [Full text of this article]