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This Article Full Text Full Text (PDF) All Versions of this Article: jnnp.2006.090613v1 77/7/811    most recent Submit a response Read responses to this article Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Perl, D P Search for Related Content PubMed PubMed Citation Articles by Perl, D P Topic Collections Relevant Article

Exposure to aluminium and the subsequent development of a disorder with features of Alzheimer’s disease

Correspondence to:
Correspondence to:
Dr Daniel P Perl
Neuropathology Division, Mount Sinai School of Medicine, New York, New York 10029, USA; daniel.perl@mssm.edu

The first 150 words of the full text of this article appear below.

The paper by Exley and Esiri¹(see p 877) reports a most unusual case, namely, a 58-year-old woman with a rapidly progressive, fatal dementing illness, who, at autopsy, shows dramatic ß-amyloid deposition of cerebral cortical and leptomeningeal blood vessels, modest numbers of neurofibrillary tangles and Lewy bodies, and evidence of very high aluminium content in affected brain regions. Of particular interest is that she was among the 20 000 people who were accidentally exposed, in July 1988, to exceedingly high concentrations of aluminium in their water supply in the so-called "Camelford incident". This is the first autopsy-documented case of Alzheimer’s disease-like neurodegeneration in a victim of this incident.

This case raises the question of whether the relatively short but massive exposure to aluminium in the water supply played a part in the development of subsequent neurological illness in this woman. The association of aluminium and Alzheimer’s . . . [Full text of this article]

Relevant Article

Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK

C Exley and M M Esiri
J. Neurol. Neurosurg. Psychiatry 2006 77: 877-879. [Abstract] [Full Text] [PDF]