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Bilateral mesial temporal polymicrogyria: a case report

¹ Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
² Department of Radiology II, Innsbruck Medical University, Innsbruck, Austria

Correspondence to:
Eugen Trinka, MD, MSc, Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria; eugen.trinka@uki.at

The first 150 words of the full text of this article appear below.

Polymicrogyria is a malformation of cortical organisation morphologically marked by an irregular brain surface with multiple excessively folded small gyri. Cortical thickness is reduced but appears increased in some areas as a result of the fusion of small gyri.¹ On magnetic resonance imaging (MRI) polymicrogyria is delineated by an abnormal gyral pattern, increased cortical thickness and irregularity of the cortical–white matter junction.²

Clinical presentation largely depends on the localisation of polymicrogyria and the extent of cortical involvement. Several topographically distinct syndromes of bilateral polymicrogyria have been described.² Polymicrogyria may be the result of acquired intrauterine insults (ischaemia, twinning, infections with cytomegalovirus, toxoplasma, varicella-zoster virus) as well as inherited (familial polymicrogyria syndromes) or metabolic disorders (Leigh syndrome, Zellweger syndrome).¹

A 26-year-old right-handed man was referred to the video-electroencephalographic monitoring unit for presurgical evaluation of medically intractable epilepsy. The patient was born after an uneventful pregnancy and delivery. His developmental milestones . . . [Full text of this article]