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Hu, Yo, Ri, Ma, Ta: monosyllabic answers to complex questions

Correspondence to:
Dr Jan Verschuuren, Leiden University Medical Centre, PO Box 9600, Leiden 2300 RC, The Netherlands; j.j.g.m.verschuuren@lumc.nl

The first 150 words of the full text of this article appear below.

Patients’ names rarely obtain a prominent place in medical history. The exotic abbreviations from the title are an exception, as some patients, who presented with a rare but intriguing neurological syndrome, lend the first two letters of their names to indicate the antigen involved in their autoimmune disease. The search for autoantibodies related to limbic encephalitis is a successful example. Anti-Hu, anti-Ma, anti-Ta and anti-NMDA receptor antibodies were discovered as paraneoplastic antibodies in patients with tumours such as lung, testicular cancer or ovarian teratomas.^{1 2} Antibodies to voltage gated potassium channels, infrequently associated with cancer, were shown to be associated with a treatable form of limbic encephalitis.³ In this issue of J Neurol Neurosurg Psychiatry, Hoffmann and colleagues⁴ expand the spectrum of paraneoplastic neurological diseases by giving a detailed description of the neurological presentation of patients with anti-Ma or anti-Ta antibodies (see page 767). These antibodies are members . . . [Full text of this article]

Relevant Article

Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases

L A Hoffmann, S Jarius, H L Pellkofer, M Schueller, M Krumbholz, F Koenig, W Johannis, C la Fougere, T Newman, A Vincent, and R Voltz
J. Neurol. Neurosurg. Psychiatry 2008 79: 767-773. [Abstract] [Full Text] [PDF]