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PAPER |
Department of Neurology, Clinical Sciences Lund, Lund University, Sweden
Correspondence to:
Correspondence to:
Ann-Cathrin Jönsson
Department of Neurology, Lund University Hospital, S-221 85 Lund, Sweden; ann-cathrin.jonsson{at}skane.se
Received 29 August 2005
In final revised form 5 December 2005
Accepted for publication 5 December 2005
 | ABSTRACT |
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 TOP ABSTRACT METHODSRESULTSDISCUSSIONREFERENCES |
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Methods: During a one year period, 416 first-ever stroke patients were included in the population based Lund Stroke Register. After 4 and 16 months (median), 297 patients (98% of survivors) were followed up. Worst pain intensity during the previous 48 hours was assessed on a visual analogue scale (VAS), range 0 to 100: a score of 0 to 30 was defined as no or mild pain; 40 to 100 as moderate to severe pain. NIH stroke scale (NIHSS) score and HbA1c were assessed at baseline. At 16 months, screening for depression was done using the geriatric depression scale (GDS-20), and cognition with the mini-mental state examination (MMSE). Predictors of pain were determined by multivariate analyses.
Results: Moderate to severe pain was reported by 96 patients (32%) after four months (VAS median = 60). Predictors of pain were younger age (p = 0.01), female sex (p = 0.006), higher NIHSS score (p<0.001), and raised HbA1c (p = 0.001) at stroke onset. At 16 months, only 62 patients (21%) had moderate to severe pain, but pain intensity was more severe (median VAS score = 70; p<0.016). Higher pain intensity correlated with female sex, worse GDS-20 score, better MMSE score, and raised HbA1c. Pain was persistent in 47%, disturbed sleep in 58%, and required rest for relief in 40% of patients.
Conclusions: Although prevalence of pain after stroke decreased with time, after 16 months 21% had moderate to severe pain. Late pain after stroke was on average more severe, and profoundly affected the patients’ wellbeing.
Abbreviations: ADL, activities of daily living; BI, Barthel index; CPSP, central post-stroke pain; DVT, deep venous thrombosis; GDS, geriatric depression scale; LSR, Lund Stroke Register; MMSE, mini-mental state examination; NIHSS, National Institutes of Health stroke scale; VAS, visual analogue scale
Keywords: pain; patient perspective; stroke; stroke management
Studies of pain in stroke survivors have often been concentrated on a clinical diagnostic perspective—for example, central post-stroke pain (CPSP), shoulder pain, or other specific types of pain.1–6 Previous studies usually involved stroke patients admitted to stroke units, geriatric clinics, general wards, or rehabilitation units.1,7,8,9,10 In these reports, the prevalence of pain after stroke has varied between 19% and 74%, and pain intensity was not measured. The prevalence of shoulder pain, one of the most common sites of pain after stroke, ranges from 11% to 40%,1–4 and of CPSP, from 8% to 35%.5,6,11 Thus the prevalence of pain after stroke has varied considerably in previous studies, presumably because of different inclusion criteria, definitions, and means of follow up. The intensity of pain has not been measured, and little is known about the evolution of pain with time.
The objectives of our study were to determine the prevalence, intensity, and location of pain from the patients’ perspectives, as well as the evolution of pain with time and predictive factors in a consecutive, population based group of stroke survivors.
| METHODS |
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TOPABSTRACTMETHODSRESULTSDISCUSSIONREFERENCES |
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All surviving patients were contacted four months after stroke onset (follow up I) and 16 months after stroke onset (follow up II) (medians) (fig 1
), and offered a personal appointment with a nurse specialist (A-CJ) and a physical therapist (IL). These two professionals undertook all follow up assessments. Pain intensity could be assessed on a visual analogue scale (VAS) in 297 patients on both follow up occasions. These 297 patients comprised 98% of all survivors at follow up II. About 70% of the patients examined were able to come to the outpatient clinic, and the others were examined in primary care centres (
10%), nursing homes (10%), or their own homes (10%).
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Baseline assessments
We registered the following baseline variables: age, sex, main type of stroke, NIH stroke scale (NIHSS) score,15 sensory disturbance (item 8 in NIHSS), hypertension (blood pressure after the acute phase 
160/90 mm Hg or pharmacologically treated), cardiac disease (defined as angina pectoris, congestive heart failure, myocardial infarction, atrial fibrillation, previous cardiac surgery), and diabetes mellitus (blood glucose 6.1 mmol/l or serum glucose 7.0 mmol/l on repeated measurements, or diagnosed earlier). Impaired glucose metabolism has been associated with joint mobility16 and shoulder impairment.17 We therefore included glycosylated haemoglobin (HbA1c, upper normal limit 5.3%) at baseline, to screen for abnormal glucose tolerance.18
Functional status before stroke was assessed by interview questions about indoor and outdoor ambulation, dressing, and toileting.19 If the patients could manage these activities of daily living (ADL) by themselves they were considered independent. Patients’ other physical activities (walking, gardening, swimming, running, and other sports) before stroke were recorded on a scale from 0 (no physical activity) to 4 (almost every day).20
The stroke location was defined as subtypes according to the Oxfordshire Community Stroke Project (OCSP) classification system: total anterior circulation syndrome (TACS), large anterior circulation infarct with both cortical and subcortical involvement; partial anterior circulation syndrome (PACS), more restricted and predominantly cortical infarcts; lacunar syndromes (LACS), infarcts confined to the territory of the deep perforating arteries; and posterior circulation syndrome (POCS), infarcts clearly associated with the vertebrobasilar arterial territory.21
Follow up assessments
At both follow up assessments, the patients’ functional status was assessed using the Barthel index (BI)22 and divided into three grades of dependence: independent (BI score, 95–100), moderate dependence (BI score, 60–90), and major dependence (BI score, 0–55).23 We used VAS for measuring the intensity of pain. Patients were asked to indicate their worst self perceived pain during the previous 48 hours on a 0 to 100 mm VAS, marked at one end "no pain" and at the other end "worst imaginable pain". The VAS scores were registered in 10 mm intervals. A VAS score of zero was defined as no pain, 10 to 30 as mild pain, and 40 to 100 as moderate to severe pain.24 Patients’ views on different aspects of pain were explored by a set of questions which included onset time, frequency, treatment, effect on sleep, site, and self perceived cause of pain. The investigators (A-CJ, IL) also assessed whether pain was caused by any of the common complications after stroke, according to previous reports1,4,5: CPSP, shoulder pain, pressure sores, or deep venous thrombosis (DVT). If the investigators suspected CPSP, the patient was referred to a neurologist, who diagnosed CPSP according to criteria described in previous studies.5,11 We also recorded the location of the pain. If the patients’ cognitive function made the assessment of pain difficult, we also interviewed the spouse, other family members, or contact persons among the nursing home personnel.
At follow up II, we tested cognitive function in 272 of the 297 patients (25 patients could not respond for physical, cognitive, or psychological reasons) using the MMSE, range 0–30,25 a score of <24 indicating cognitive impairment.26,27
We screened for depression in 288 patients (nine could not respond for physical, cognitive, or psychological reasons) with the Swedish adapted geriatric depression scale, GDS-20 (range 0–20). A score of 6 indicates possible depression.27–29
Statistical analysis
Using Mann–Whitney test and 
2 tests, we examined if there was an association between the prevalence of moderate to severe pain at both follow up assessments and the specified baseline variables. We also tested with Mann–Whitney test whether there was an association between moderate to severe pain and the Barthel index at each follow up. At follow up II we additionally tested for a possible relation between prevalence of moderate to severe pain and the MMSE and GDS-20 scores. The individual VAS scores of the patients with moderate to severe pain at follow up I and II, respectively, were compared using Wilcoxon signed ranks test. The association of VAS scores at follow up I with the baseline variables, and also with the Barthel index at follow up I, was tested by multivariate stepwise regression analysis. A similar analysis was used to test for an association between VAS scores at follow up II and the baseline variables, the Barthel index at follow up II, the MMSE score, and the GDS-20 score. Probability (p) values of <0.05 were considered significant.
| RESULTS |
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TOPABSTRACTMETHODSRESULTSDISCUSSIONREFERENCES |
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.
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). The 119 patients who did not participate in our study were in most cases deceased (84 patients); they were also older (mean age 79.7 years) or had more severe strokes, or both. Before stroke onset, 98% of the 297 survivors were independent in ADL. They had a comparatively low NIHSS score (mean score = 5) at baseline. Grades of dependency at follow up I and II, respectively, were: 73%/70% independency; 19%/19% moderate dependency; and 8%/11% major dependency. Women had significantly lower Barthel index scores than men (p = 0.038).
At follow up II, 34% of the patients with no or mild pain and 57% of the patients with moderate to severe pain scored 6 on the GDS-20 depression scale (p<0.001). In the group with no or mild pain, 19% scored <24 (that is, cognitive impairment) on the MMSE scale, but only 9% scored <24 in the group with moderate to severe pain (p = 0.05). Pain characteristics reported by the patients are presented in table 2.
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). At follow up II, the proportion of patients with moderate to severe pain had decreased to 21% (32 men and 30 women), while 12 patients reported mild, and 223 patients no pain. Testing for sex differences within the groups with moderate to severe pain, we found that the mean VAS scores for men/women were 59/66 (NS) at follow up I and 65/72 (p = 0.044) at follow up II.
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For patients with moderate to severe pain, evolution with time differed with respect to cause and location of pain (table 2). Among the 96 patients with moderate to severe pain at follow up I, the cause of pain was reported to be stroke by 51%, other reasons by 43%, and of unknown cause by 6%. Among the 62 patients with moderate to severe pain at follow up II, a smaller proportion (36%) reported the cause of pain to be stroke, 56% reported other reasons, and 8% cause unknown. The investigators judged the cause of moderate to severe pain to be stroke related in 57% of the cases at follow up I and in 37% at follow up II. Among the 57 patients with pain in the upper limbs at follow up I, 44 (77%) had shoulder pain. At follow up II, there were only 28 patients with pain in the upper limbs and 19 (68%) of these had shoulder pain. There were only four patients (1%) diagnosed with CPSP. Pressure sores and DVT were not found as a cause of pain in any of the patients.
The 96 patients with moderate to severe pain at follow up I experienced considerable improvement between the two follow up assessments, in both the upper and the lower limbs (table 2). Compared with follow up I, the proportion of individuals with pain in the upper limbs decreased from 60% to 45% (p<0.001) at follow up II, whereas in the lower limbs there was a small but non-significant increase from 35% to 39%. Among the 62 patients with moderate to severe pain at follow up II, there were only minor changes since follow up I in the proportion of individuals with pain in the upper limbs (from 50% to 45%, NS) and in the lower limbs (from 31% to 39%, NS).
The patients’ self reports on pain characteristics are detailed in table 2. Pain was constantly present for 30%/47% at the two follow up assessments, and often present for 68%/52%. Disturbed sleep because of pain was reported by no less than 49%/58% of the patients with moderate to severe pain. The proportion requiring temporary rest to obtain pain relief was 50%/40% and movement/changing position gave pain relief in about a quarter of the patients at both follow up assessments. Half or more of the patients were not relieved from pain by drug treatment and few had tried alternative treatment methods. Physical therapy had been used by only 19%/16% of the patients. Very few patients had tried acupuncture or transcutaneous nerve stimulation.
Factors related to pain
The following baseline factors were significantly associated with moderate to severe pain at follow up I in univariate analyses: sex (p = 0.046), sensory disturbance (p = 0.003), and HbA1c (p = 0.04). Barthel index at follow up I was also related to moderate to severe pain (p = 0.001). At follow up II, GDS-20 scores were associated with moderate to severe pain (p<0.001). In a multivariate stepwise regression analysis, younger age (p = 0.01), female sex (p = 0.006), higher NIHSS score (p<0.001), and higher HbA1c value (p = 0.001) at baseline were significant predictors of more intense pain (higher VAS scores) at follow up I after stroke. At follow up II, a multivariate stepwise regression analysis showed a correlation between higher VAS scores and the following factors: female sex (p = 0.036), higher (worse) GDS-20 score (p = <0.001), higher (better) MMSE score (p = 0.004), and higher HbA1c baseline values (p = 0.004). When doing separate multivariate analyses comparing only possible predictive factors with VAS scores as the dependent variable, we found that besides the mentioned significant baseline variables the clinical stroke subtype LACS (p = 0.044) was associated with higher intensity of pain at follow up I, and younger age (p = 0.006) correlated with higher VAS scores at follow up II.
| DISCUSSION |
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TOPABSTRACTMETHODSRESULTSDISCUSSIONREFERENCES |
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Strengths of our study are the population based design, well characterised patient material, and >90% follow up, achieved by examining almost one third of all patients in out of hospital settings. Weaknesses of our study include lack of data on cerebrovascular and other main new events after the index stroke and lack of information on the type and dose of analgesic drug treatment given during the follow up.
One of our main findings was that pain in stroke patients is of a very complex nature. In some cases it was hard to determine whether pain was clearly stroke related or not. Even with pain onset before stroke, the pain intensity could change after the stroke. The pain could be on the same side as the stroke symptoms, or it could be on the opposite side, in both cases possibly related to differences in the patient’s balance or motor function, causing stroke induced abnormalities in posture and gait,30 or other effects of the stroke. Our study focused on the patient’s perspective of pain and how the pain affected the patient’s daily life. It is of course also important to determine clinical diagnoses for pain conditions needing special pharmacological treatment—for example, CPSP—in order to offer the patients the required drug, and this was done for the few cases found in our cohort.
One novel finding was that about half the patients with moderate to severe pain early after stroke had no pain at follow up II. However, the group with moderate to severe pain at follow up II had more intense pain than at follow up I, indicating dynamic changes in the occurrence and characteristics of pain after stroke. As in studies of selected groups of stroke patients,1–6 we found that one of the most common sites of pain after stroke was the upper limbs, but the prevalence of pain in the upper limbs decreased with time. We intend to further analyse the group with shoulder pain in a separate report.
Another novel finding was that as many as 38–40% of the patients with moderate to severe pain at the two follow up assessments already had pain before their stroke. Because we had our first contact with the patients as the result of their first-ever stroke, it was not possible to record VAS scores for pain in the past. Consequently we were unable to measure accurately whether stroke aggravated pre-existing pain. No less than 31% (follow up I) and 26% (follow up II) of the patients with moderate to severe pain had experienced pain already within two weeks of stroke onset. In a study of chronic musculoskeletal regional pain (regional and widespread) in a general community based Swedish population (20 to 74 years, n = 2755), the age and sex adjusted prevalence was 34.5%.31 This study group is interesting for comparison because pain in the upper and lower limbs was the most common site of pain in our patient group. The association between higher VAS scores and female sex is similar to the findings in another study reporting that there may be sex differences in the presentation of symptoms in stroke patients.32 Women’s lower Barthel index score—that is, more impaired functional status—may also contribute to their greater intensity of pain.
The proportion of patients with cognitive decline was significantly larger in the group with no or mild than moderate to severe pain at follow up II. The reason for this is unclear. Cognitively impaired people may be less physically active and therefore avoid movements which provoke pain attacks. It is also possible that some cognitively impaired patients had difficulties in scoring their pain correctly, even if we tried to guide them in how to use the VAS scale.
Previous reports have suggested an association between joint pain, impaired glucose metabolism, and cerebrovascular disease.16,17 Although diabetes mellitus is well documented as a cause of pain, we did not find any such relation in the present study. However, we found a correlation between pain and raised HbA1c at baseline, which is of interest but needs to be corroborated by further studies.
As presented in table 2, pain had a profound effect on the patients’ life situation, because the self perceived frequency of pain was "constant" for 30%/47% and "often" for 68%/52% of the patients with moderate to severe pain at the two follow up assessments. More than half of the patients had difficulties with sleeping because of pain. Lack of sleep may contribute to the post-stroke fatigue which is one of the most common impairments after stroke.33–35 Because only 42% and 50% of the patients with moderate to severe pain at follow up I and II, respectively, reported relief from pain by drug treatment and one of five patients had tried medication earlier with no effect (table 2), it is possible that pharmacological treatment had not been used sufficiently. Alternative methods reported to relieve pain were movement/changing position (25/24%), rest (50/40%), and physical therapy (5/5%). This concurs with the results of a previous study of pain in a smaller group of stroke patients, showing that other methods besides drug treatment may help to relieve pain.35 Our finding of a correlation between functional status, depressed mood, and pain agrees with findings in a previous study of elderly patients.36
Our study shows that pain, as reported by patients, is common both early and late after stroke. Although the prevalence of pain after stroke decreased with time, after 16 months, one in five patients had moderate to severe pain. Late pain after stroke was on average more severe, and profoundly affected wellbeing and physical activity. In routine follow up programmes, pain after stroke may be underrecognised and undertreated.
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| ACKNOWLEDGEMENTS |
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| FOOTNOTES |
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Published Online First 14 December 2005
Competing interests: none declared
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