Neurology and medicine
Neurology and the skin
a Neuroscience
Research, SmithKline Beecham Pharmaceuticals, New Frontiers
Science Park North H25/124, Third Avenue, Harlow, Essex, UK, b Department of Dermatology, The Johns
Hopkins University School of Medicine, 10 th Floor, 550 North Broadway,
Baltimore, MD, USA
Correspondence to: Dr Orest Hurko, Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North H25/124, Third Avenue, Harlow, Essex CM19 5AW, UK. Telephone 0044 1279 622 739; fax 00441279 622 371; email Orest_2_Hurko@sbphrd.com
Received 14 August
1998 and in revised form 9 November 1998;
Accepted 10
November 1998
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
Many
disorders affect both the nervous system and the skin. The
complementary
and some would saydiametrically oppositeclinical methods of the dermatologist and the neurologist can in these circumstances reduce an otherwise dauntingly large differential into a
more tractable, smaller list. Often triangulation with these and other
clinical findings is sufficient for accurate diagnosis, but in other
cases, serological or genetic data must be considered before diagnosis
is secure.
We have purposely avoided traditional groupings such as phakomatoses,
and immunological, infectious, or genetic diseases. Such distinctions
are becoming increasingly obscure. Instead, we have organised the
roughly 300 disorders with manifestations both in the skin and nervous
system into clinically relevant groupings, as they may be first
encountered by a practicing physician: neurocutaneous disorders
associated with impaired immunity; stroke; neuropathy; meningitis or
meningoencephalitis; vesicular lesions; ecchymoses, non-palpable
purpura, and petechiae; cafe au lait spots; amyloidosis; rheumatoid
arthritis; cutaneous vasculitis; photosensitivity; and
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