Letters to the editor
Creutzfeldt-Jakob-like syndrome induced by lithium, levomepromazine, and phenobarbitone
| The first 150 words of the full text of this article appear below. |
Creutzfeldt-Jakob-like syndrome was first reported by Smith and Kocen1 in 1988. Its symptoms resemble Creutzfeldt-Jakob disease but it is induced by drugs, particularly lithium, and most patients recover without sequel after discontinuation of drugs. It also displays a characteristic EEG similar to Creutzfeldt-Jakob disease, but this returns to normal when the patient recovers.
There have been some case reports of Creutzfeldt-Jakob-like syndrome
after that of Smith et al (table), but no
paper seems to have described the detailed course of EEG changes. This
paper presents a case of Creutzfeldt-Jakob-like syndrome possibly
induced by lithium, levomepromazine, and phenobarbitone, in which we
succeeded in recording the course of EEG changes.
| Table Removed (Available Only in the Full Text) |
A 65 year old woman was admitted to a hospital with coma and myoclonus.
She had a history of manic and depressive disease for 8 years and had
been treated with 200 mg lithium carbonate, 25 mg chlorpomazine, and 10 mg levomepromazine daily. Her first symptom was forgetfulness
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