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Reversal of tetrabenazine induced depression by selective noradrenaline (norepinephrine) reuptake inhibition
  1. WOLFGANG SCHREIBER,
  2. JÜRGEN-CHRISTIAN KRIEG
  1. Department of Psychiatry and Psychotherapy, Philipps-University, Rudolf-Bultmann-Straβe 8, D-35033 Marburg/Lahn, Germany
  2. Department of Neurology, Philipps-University, Rudolf-Bultmann-Straβe 8, D-35033 Marburg/Lahn, Germany
  1. Dr Wolfgang Schreiber, Department of Psychiatry and Psychotherapy, Philipps-University, Rudolf-Bultmann-Straβe 8, D-35033 Marburg/Lahn, Germany. Telephone 0049 6421 286277; fax 0049 6421 285229; emailschreibe{at}mailer.uni-marburg.de
  1. TOBIAS EICHHORN
  1. Department of Psychiatry and Psychotherapy, Philipps-University, Rudolf-Bultmann-Straβe 8, D-35033 Marburg/Lahn, Germany
  2. Department of Neurology, Philipps-University, Rudolf-Bultmann-Straβe 8, D-35033 Marburg/Lahn, Germany
  1. Dr Wolfgang Schreiber, Department of Psychiatry and Psychotherapy, Philipps-University, Rudolf-Bultmann-Straβe 8, D-35033 Marburg/Lahn, Germany. Telephone 0049 6421 286277; fax 0049 6421 285229; emailschreibe{at}mailer.uni-marburg.de

https://doi.org/10.1136/jnnp.67.4.550

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    Tetrabenazine (TBZ), a synthetic benzoquinolizine, was first introduced as a neuroleptic agent in 1960, and is now widely used in the treatment of hyperkinetic movement disorders such as chorea, tics, or tardive dyskinesia. The side effect profile is mainly characterised by the triad of drowsiness/fatigue, parkinsonism, and depression; depression is found in about 15% of patients treated with TBZ.1 We here report on the rapid reversal of depressive symptoms in a patient treated with TBZ for orofacial dystonia by administering the new and highly selective noradrenaline (norepinephrine) …

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