J Neurol Neurosurg Psychiatry 2000;68:2-5 ( January )

Editorial

Neurology of Whipple's disease

The first 150 words of the full text of this article appear below.

In 1907, George Hoyt Whipple, then an instructor in pathology at Johns Hopkins University, published a case report of a 36 year old physician who had been domiciled in Constantinople.¹ He developed recurring arthropathy, weight loss, and steatorrhoea, became worse, and died. At necropsy the intestine and mesenteric lymph glands were infiltrated by mononuclear and polynuclear giant cells and deposits of fat and fatty acids. Whipple described the large "foamy" mononuclear cells in the intestinal mucosa which were later shown to contain periodic acid Schiff (PAS) positive material. The aetiology of the condition was not established and he wrote "Gland tissue treated by the Levaditi method shows great numbers of a peculiar rod-shaped organism (?) which does not stain by the aniline dyes . . ." Whether this is the aetiological factor in this disease cannot be determined from this case". A prescient observation. He suggested intestinal lipodystrophy as a name for the . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Patel, S. J., Huard, R. C., Keller, C., Foca, M. (2008). Possible Case of CNS Whipple's Disease in an Adolescent With AIDS. J Int Assoc Physicians AIDS Care (Chic Ill) 7: 69-73 [Abstract]  
• Panegyres, P.K., Edis, R., Beaman, M., Fallon, M. (2006). Primary Whipple's disease of the brain: characterization of the clinical syndrome and molecular diagnosis. QJM 99: 609-623 [Abstract] [Full Text]  
• Wills, A J, Pengiran Tengah, D S N A, Holmes, G K T (2006). The neurology of enteric disease. J. Neurol. Neurosurg. Psychiatry 77: 805-810 [Full Text]  
• Murray, K., Shorvon, S., Smith, C., Roberts, R., Warlow, C. (2006). A young man with bilateral epilepsia intractable and partialis continua. PN 6: 34-41 [Full Text]  
• Drevets, D. A., Leenen, P. J. M., Greenfield, R. A. (2004). Invasion of the Central Nervous System by Intracellular Bacteria. Clin. Microbiol. Rev. 17: 323-347 [Abstract] [Full Text]  
• Peters, G, Du Plessis, D G, Humphrey, P R (2002). Cerebral Whipple's disease with a stroke-like presentation and cerebrovascular pathology. J. Neurol. Neurosurg. Psychiatry 73: 336-339 [Abstract] [Full Text]  
• Bosman, C., Boldrini, R., Borsetti, G., Morelli, S., Paglia, M. G., Visca, P. (2002). Sicca Syndrome Associated with Tropheryma whipplei Intestinal Infection. J. Clin. Microbiol. 40: 3104-3106 [Abstract] [Full Text]  
• Messori, A., Bella, P. D., Polonara, G., Logullo, F., Pauri, P., Haghighipour, R., Salvolini, U. (2001). An Unusual Spinal Presentation of Whipple Disease. Am. J. Neuroradiol. 22: 1004-1008 [Abstract] [Full Text]  
• Fenollar, F., Raoult, D. (2001). Whipple's Disease. CVI 8: 1-8 [Full Text]