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Journal of Neurology, Neurosurgery, and Psychiatry 2000;68:681-682; doi:10.1136/jnnp.68.5.681
Copyright © 2000 by the BMJ Publishing Group Ltd.
J Neurol Neurosurg Psychiatry 2000;68:681-682 ( May )

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Myelopathy associated with Hashimoto's disease

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Encephalopathy associated with Hashimoto's disease was first reported by Brain et al in 1966.1 Hashimoto's encephalopathy is a steroid responsive relapsing disorder associated with Hashimoto's disease that often presents with stroke-like episodes, myoclonus, and cognitive impairment. Diagnostic testing usually shows a euthyroid state with increased thyroid autoantibodies, increased CSF protein, and EEG abnormalities.2 3 We present the first case of myelopathy associated with Hashimoto's disease, followed 2 months later by encephalopathy.

A 70 year old housewife was admitted to our hospital on 28 July 1997. Her leg had felt heavy for a month, and she was unable to walk for several days before admission due to weakness in the left leg. She had been diagnosed with Hashimoto's disease at the age of 57 and treated with thyroxin. On January 11 1988, she had developed dysesthesia and weakness in the left arm and leg. Brain CT, radiography of the cervical spine, and CSF findings were normal at this time. . . . [Full text of this article]


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This article has been cited by other articles:

  • Ferracci, F., Moretto, G., Candeago, R. M., Cimini, N., Conte, F., Gentile, M., Papa, N., Carnevale, A. (2003). Antithyroid antibodies in the CSF: Their role in the pathogenesis of Hashimoto's encephalopathy. Neurology 60: 712-714 [Abstract] [Full Text]  

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