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Zeta class glutathione transferase polymorphisms and Parkinson's disease
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Glutathione transferase genes (GST) are candidate genes for Parkinson's disease because they are involved with the metabolism of pesticides, dopamine, and glutathione. Recent reports have suggested an association between Parkinson's disease and polymorphisms of GSTP11 or GSTM1 and GSTT1.2
Recently we discovered a new polymorphic site in the zeta class G
T
(GSTZ1) gene.3 This consists of
a C6T transition at nucleotide 245 in exon 5 that results in an amino
acid change at position 82 from methionine to threonine. The T
substitution occurs in 14% of white people. We have previously
reported two other polymorphic sites at nucleotides 94 and 124 in exon
3.4 There are now thought to be four alleles of GSTZ1:
Z1*A
(A94A124C245), Z1*B
(A94G124C245),
Z1*C
(G94G124C245,) and
Z1*D
(G94G124T245). Here we investigated
the association of Parkinson's disease, pesticide exposure, and these
GSTZ1 polymorphisms.
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