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Lymphadenopathy in patients with multiple sclerosis undergoing treatment with glatiramer acetate
| The first 150 words of the full text of this article appear below. |
Glatiramer acetate (GA)
formerly known as copolymer 1 or
COP-1has been shown to reduce the frequency of relapses and disease activity and burden as measured by MRI in patients with
relapsing-remitting multiple sclerosis (RR-MS).1 The
mechanism of action is thought to involve MHC-II blockade2
and the induction of a Th2/Th3 cytokine response.3
Peripheral blood mononuclear cells from patients with multiple
sclerosis and healthy controls proliferate in reponse to GA in
vitro.4 Therefore GA seems to
have both immunostimulatory and immunomodulatory potential.
In our centre 27 patients with relapsing-remitting or
relapsing-progressive multiple sclerosis were treated with 20 mg
subcutaneous GA daily for 3 years as part of an open label
multicentre study. Safety evaluation and expanded disability status
scale (EDSS) rating were performed every 3 months and in the 3rd year
every 6 months and when clinical relapses occurred. Relapses were
defined according to Poser criteria and annual relapse rates were
calculated for the 3 year study
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Nolden, S, Casper, C, Kuhn, A, Petereit, H F
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Langer-Gould, A., Moses, H. H., Murray, T. J.
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[Abstract] [Full Text] -
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(2003). Glatiramer Acetate (Copolymer-1, Copaxone) Promotes Th2 Cell Development and Increased IL-10 Production Through Modulation of Dendritic Cells. J. Immunol.
170: 4483-4488
[Abstract] [Full Text]
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