© 2002 Journal of Neurology Neurosurgery and Psychiatry
LETTER
Miller-Fisher syndrome and Hodgkin’s disease
Departments of Neurology and Haematology, Hospital Juan Canalejo, La Coruña, Spain
Correspondence to:
Correspondence to:
Dr E Rubio-Nazabal, Servicio de Neurología, Hospital Juan Canalejo, As Xubias sn, 15006 La Coruña, Spain;
jmareyl@telefonica.net
Keywords: Miller-Fisher syndrome; Guillain-Barré syndrome, Hodgkin’s disease
| The first 150 words of the full text of this article appear below. |
Miller-Fisher syndrome (MFS) is a rare clinical entity classically regarded as a variant of Guillain-Barré syndrome (GBS) and characterised by the clinical triad of ophthalmoplegia, ataxia and areflexia.1 In MFS, paralysis is restricted to extraocular and occasionally other craniobulbar muscles. We report on a patient with a relapsing Hodgkin’s disease who developed MFS. Conventional immunosuppressive and intravenous immunoglobulin treatments improved the neurological deficits.
This 27 year old white man who had an eight year history of Hodgkin’s disease (type mixed cellularity, pathological stage IVB) had been receiving a salvage ESHAP regimen (etoposide VP-16 68 mg/day, methylprednisolone 500 mg/day, and cisplatin 42.5 mg/day for four days and cytosinearabinoside 3.4 g/day on the fifth day) since the first disease relapse four months before admission. He was admitted to the hospital for constitutional symptoms (39°C fever, recurrent night sweats, fatigue, malaise, and weakness). There was no history of infection. General examination was unremarkable
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