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The most recent version of this article was published on 1 March 2006

J Neurol Neurosurg Psychiatry. Published Online First: 15 August 2005. doi:10.1136/jnnp.2005.073999
Copyright © 2005 by the BMJ Publishing Group Ltd.
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Short reports

Cardiac 123I-MIBG Scintigraphy in Patients with Drug- Induced Parkinsonism

Phil Hyu Lee 1*, Joong Seok Kim 2, Dong Hoon Shin 1, Seok-Nam Yoon 3 and Kyoon Huh 1

1 Department of Neurology, Ajou University School of Medicine, Korea, Republic of
2 Department of Neurology, Catholic University of Korea, Korea, Republic of
3 Nuclear Medicine,Ajou University School of Medicine, Korea, Republic of

* To whom correspondence should be addressed. E-mail: phisland{at}chol.net.

Accepted 10 August 2005


*  Abstract

We investigated cardiac sympathetic dysfunction using 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 20 patients with drug-induced parkinsonism (DIP). The mean heart to mediastinum ratio was significantly greater in patients with DIP than in those with Parkinson's disease (2.07 ± 0.39 vs 1.28 ± 0.15, p<0.001). MIBG uptake was not different between the DIP patients and the controls. Two DIP patients whose MIBG uptake was significantly reduced exhibited persistent parkinsonism and responded dramatically to levodopa.

Keywords: cardiac MIBG, drug-induced parkinsonism




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P. H. Lee, S. H. Yeo, S. W. Yong, and Y. J. Kim
Odour identification test and its relation to cardiac 123I-metaiodobenzylguanidine in patients with drug induced parkinsonism
J. Neurol. Neurosurg. Psychiatry, November 1, 2007; 78(11): 1250 - 1252.
[Abstract] [Full Text] [PDF]


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