Topiramate, nutrition and weight change: a prospective study
Karl Martin Klein 1*, Frank Theisen 2, Susanne Knake 1, Wolfgang H. Oertel 1, Johannes Hebebrand 3, Felix Rosenow 1 and Hajo M. Hamer 1
1 Interdisciplinary Epilepsy Center, Department of Neurology, Philipps University, Marburg, Germany, Germany
2 Interdisciplinary Epilepsy-Center, Department of Child and Adolescent Psychiatry, Philipps Universit, Germany
3 Department of Child and Adolescent Psychiatry, University Duisburg-Essen, Germany, Germany
* To whom correspondence should be addressed. E-mail: klein.km{at}staff.uni-marburg.de.
Accepted 22 November 2007
 | Abstract |
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Purpose: To evaluate prospectively the relationship between appetite, food composition, nutritional habits and weight loss under topiramate (TPM) and to identify predictors for TPM induced weight loss.
Methods: 22 epilepsy patients who were started on TPM were prospectively followed for six months and contacted again after a mean follow-up time of 37.1 months.
Results: BMI loss occurred in 59% of the patients with a mean weight loss of 9.5 kg after 6 months on TPM without further weight loss at long term follow-up. Weight loss went along with reduction in appetite without affecting food composition. Predictors for BMI loss after 6 months were high initial BMI and body fat. At 3 weeks on TPM, the recorded parameters did not predict BMI loss but at 3 months weight loss, reduction of appetite and amount of food intake were predictive for the amount of BMI loss after 6 months.
Keywords:
adverse effects, antiepileptic agents, body fat, food composition, weight loss
