Cerebrospinal fluid dynamics were studied in 14 dogs with spontaneous hydrocephalus. In nine of the dogs aqueductal obstruction was observed and the remainder had a `communicating type' hydrocephalus. The major histological findings consisted of severe ependymal destruction, spongy changes in the periventricular white matter, increased density of capillaries in this area, and varying degrees of thickening, fibrosis, and fusion of the choroid villi. The formation and absorption of CSF were studied by perfusion of the cerebral ventricles. The rate of formation of CSF was found to decrease with perfusion pressure by Vf = 0·02595−0·00022 P ml./min (P = pressure in cm H2O). The absorption of spinal fluid was found to increase linearly with pressure by Va = 0·0165 + 0·00050 P. The various factors influencing the formation and absorption of the spinal fluid are discussed. The meaning and attainment of `arrest' of the hydrocephalic process in terms of the measured rates of CSF formation and absorption in these animals are considered.
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↵2 Present address: Department of Neurosurgery, Hebrew-Hadassah Medical School, Jerusalem, Israel.
↵3 Dr. Hochwald is a recipient of a Special Research Fellowship Award no. 2 F 11 NB-01431 from the USPHS. (Reprint requests to GMH.)
↵4 Present address: Animal Medical Center, Section of Neurology, Department of Medicine, N.Y.C., N.Y.
↵1 This study is supported by Grants no. NB-06599 and no. 05024 from the USPHS.
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