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Cortisol in the cerebrospinal fluid of patients suffering from affective disorders
  1. Alec Coppen,
  2. B. W. L. Brooksbank,
  3. R. Noguera,
  4. D. A. Wilson
  1. Medical Research Council Neuropsychiatric Research Unit, Carshalton, Surrey
  2. Medical Research Council Neuropsychiatric Research Unit, at West Park Hospital, Epsom, Surrey

    Abstract

    Cortisol concentration was estimated by a competitive protein-binding method in the lumbar cerebrospinal fluid (CSF) of patients suffering from depression or from mania, and compared with the CSF cortisol concentration of neurological control patients not suffering from an affective disorder. There were no significant differences between the groups.

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