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Effect of a delayed-action phenytoin preparation on blood phenytoin concentration
  1. F. Bochner,
  2. W. D. Hooper,
  3. J. H. Tyrer,
  4. M. J. Eadie
  1. Department of Medicine, University of Queensland, Brisbane, Australia


    In a cross-over study in a group of epileptic patients it was shown that replacement of the evening dose of an ordinary phenytoin preparation with the same phenytoin dose in a delayed-action preparation produced no significant change in the next morning's mean blood phenytoin concentration. However, replacement of the entire daily dose of an ordinary phenytoin preparation with the delayed-action preparation did increase mean blood phenytoin levels after some days, possibly because the latter preparation contained an additional 6% active drug, as compared with the former. In most circumstances, it seems doubtful if the delayed-action preparation offers any advantage over ordinary phenytoin in treating epilepsy.

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