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Subacute spongiform encephalopathy
  1. J. J. Bubis,
  2. Y. Goldhammer,
  3. J. Braham
  1. Department of Cell Biology and Histology, Tel-Aviv University, Medical School, Tel-Hashomer, Israel
  2. Department of Pathology, Tel-Aviv University, Medical School, Tel-Hashomer, Israel
  3. Department of Neurology, Tel-Aviv University, Medical School, Tel-Hashomer, Israel
  4. Ch. Sheba Medical Centre, Tel-Hashomer, Israel

    Abstract

    Electron microscopic changes in brain biopsies from two cases of subacute spongiform encephalopathy are described. Large vacuoles seen in astrocytic and neuronal processes were surrounded by one or more concentric membranes. Dense-core vesicles were found in axonal endings and in nerve cell perikarya; these particles could represent catecholamine-containing vesicles.

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    Electron microscopic studies

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