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Articles
Brocresine in Parkinson's disease
Action of a peripheral and central decarboxylase inhibitor in potentiating levodopa
Abstract
Brocresine, an aromatic L-amino acid decarboxylase inhibitor with both a peripheral and central action was shown to potentiate the therapeutic effect of levodopa in Parkinson's disease. The search for useful decarboxylase inhibitors therefore need not be limited to agents that do not pass the blood/brain barrier.