Article Text


Neuromuscular block after intra-arterially injected acetylcholine
  1. P. Pinelli,
  2. P. Tonali,
  3. D. Gambi
  1. Clinic of Nervous and Mental Diseases, Catholic University, Rome, Italy


    It has been suggested that the effect of ACTH in myasthenia gravis may be ascribed to an action involving neuromuscular transmission which favours repolarization processes, with a tendency towards hyperpolarization of the membranes of muscle fibres and motor nerve endings. A similar mechanism has been postulated for the action of ACTH in epilepsy (Klein, 1970). A direct or indirect action on nerve membrane would interfere with depolarization. There is evidence of raised concentration of intracellular potassium and increased outflow of sodium ions which would cause hyperpolarization of the membrane. This paper studies the effect of ACTH on the late block of neuromuscular transmission caused by acetylcholine (ACTH).

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