Article Text

PDF

Intracranial volume–pressure relationships during experimental brain compression in primates
  1. Peter Leech,
  2. J. Douglas Miller
  1. University Department of Neurosurgery, Institute of Neurological Sciences, Glasgow

    1. Pressure responses to changes in ventricular volume

    Abstract

    Intermittent additions of 0·05 ml saline were made into the lateral ventricle of anaesthetized, ventilated baboons at regular intervals during continuous inflation of a supratentorial extradural balloon. Close correlation was observed both between the increase in ventricular fluid pressure (VFP) immediately after the injection and the volume in the balloon (P < 0·001); and between the increase in ventricular pressure and the pressure immediately before the injection (P < 0·001). This change in ventricular fluid pressure, which is termed the volume–pressure response (VPR), helps to delineate the stage reached on the intracranial volume–pressure curve, and is therefore a measure of the capacity of the intracranial contents to compensate for the volume changes produced by an expanding intracranial lesion. The VPR is currently being used in patients and the clinical implications of confirming its validity experimentally are therefore discussed.

    Statistics from Altmetric.com

    1. Pressure responses to changes in ventricular volume

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.