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Encephalitis associated with carcinoma
  1. Allen M. Kaplan,
  2. Hideo H. Itabashi1
  1. Department of Pathology, Harbor General Hospital, Torrance, California, U.S.A.
  2. Department of Neurology, Harbor General Hospital, Torrance, California, U.S.A.
  3. Department of Pediatrics, Harbor General Hospital, Torrance, California, U.S.A.

    Central hypoventilation syndrome and cytoplasmic inclusion bodies

    Abstract

    A case of encephalitis associated with a remote and occult oat cell carcinoma is presented in which the main clinical features were progressive dementia and central hypoventilation syndrome. The only significant anatomical lesions within the known anatomical substrate of respiration affected the locus caeruleus on both sides. It is speculated that the degeneration of the locus caeruleus was responsible for the central hypoventilation syndrome. Hitherto undescribed neuronal intracytoplasmic eosinophilic inclusions were found in an isolated lesion of the insular cortex. Electron microscopy failed to disclose viral particles in the regions of neuronal degeneration.

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    Central hypoventilation syndrome and cytoplasmic inclusion bodies

    Footnotes

    • 1 Address for reprint requests: Dr Itabashi, Department of Pathology, Harbor General Hospital, 1000 West Carson Street, Torrance, California 90509, U.S.A.

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