Article Text

PDF

Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease
  1. J. D. Parkes,
  2. R. C. Baxter,
  3. C. D. Marsden,
  4. J. E. Rees
  1. The University Department of Neurology, Parkinson's Disease Clinic, King's College Hospital, London
  2. The Maudsley Hospital, London

    Abstract

    Fourteen slightly disabled patients with Parkinsonism were treated separately with benzhexol, amantadine, and levodopa. Benzhexol and amantadine both gave a 15% reduction in functional disability and levodopa a 36% reduction. Benzhexol lessened the rigidity and improved the flexion of posture of Parkinson's disease, but had little or no effect on akinesia and tremor. Amantadine and levodopa caused improvement in all these symptoms. The combination of benzhexol and amantadine was as effective after four weeks of treatment as levodopa was after six months.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.