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Attempted use of haloperidol in the treatment of L-dopa induced dyskinesias
  1. Harold L. Klawans, Jr.2,
  2. William J. Weiner
  1. Department of Neurological Sciences, Rush Medical College, Chicago, Illinois, U.S.A.
  2. Department of Medicine (Section of Pharmacogenetics), Rush Medical College, Chicago, Illinois, U.S.A.

    Abstract

    Haloperidol was used in 12 patients in an attempt to improve l-dopa induced dyskinesias. In eight patients any improvement in dyskinesias was associated with increased Parkinsonism. In four patients the dyskinesias initially improved without clinical deterioration. Within several weeks, however, the disability due to Parkinsonism increased in these four patients as well. These observations suggest that long term haloperidol does not effectively decrease l-dopa induced dyskinesias without worsening Parkinsonism.

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    Footnotes

    • 2 Present address: Division of Neurology, Michael Reese Medical Center, Chicago, Ill. 60616, U.S.A.

    • 1 This work was supported by a grant from the United Parkinsonism Foundation, Chicago, Illinois.

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